South End Dining Room
October 1, 2013
11:45 AM to 12:35 PM
Dr. José Giner, Associate Professor of Organic Chemistry, SUNY-ESF
Abstract: Consideration of the biosynthesis of natural products can lead to improved methods in chemical synthesis. A hypothetical mechanism for the biochemical formation of an antiviral drug found in a marine sponge led to the discovery of an efficient way to prepare orthoesters, a rare but important functional group. Applications of this reaction will be presented in the synthesis of a natural insecticide from petunias. Mechanistic studies involving C-13 NMR with O-18 labeling will be presented, as well as some general synthetic applications of this new biomimetic reaction.
Science & Math Colloquium