Colloquium: Synthesis and Biological Evaluation of Small Molecule Heterocycles

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Date

April 2 @ 11:30 am - 12:20 pm

Place

Dining Hall

Dr. Erin Pelkey, Professor of Chemistry, joined the faculty of Hobart and William Smith Colleges in 2001.

Abstract:
We have developed convergent strategies for preparing diaryl-substituted furanones and pyrrolinones from the corresponding tetronic and tetramic acids, respectively.  The anti-proliferative activity (anti-cancer activity) of the synthesized compounds were evaluated in U-937 leukemia cells.  This talk will describe the development of the synthetic methodology along with the structure-activity relationships that have emerged from the biological testing in U-937 cells (latter done in collaboration with Professor Patricia Mowery, biology).  To date, the most potent analogs included furanones (over pyrrolinones) with indole substitution at the 3-position (compared to the 4-position). The interdisciplinary project has engaged a number of undergraduate research students over the years studying chemistry, biochemistry, and biology.

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